Scientists at the Johns Hopkins University School of Medicine claim to have determined the proper dose levels needed to create positive changes in attitudes, mood, life satisfaction, and behavior that persist for more than a year with the psychoactive substance in so-called "magic mushrooms."
"In our laboratory, weʼre working with the pure chemical psilocybin, which we can measure out precisely," he added. "We wanted to take a methodical look at how its effects change with dosage. We seem to have found levels of the substance and particular conditions for its use that give a high probability of a profound and beneficial experience, a low enough probability of psychological struggle, and very little risk of any actual harm."
In my experience with drugs many many years ago, psilocybin was by far the most pleasant and uplifting drug I ever did. LSD gave a similar high, but tended to make you feel crappy afterward. Psilocybin had a very clean and pleasant come down, and just left you feeling very happy. I never did ecstasy or DMT or speed or peyote/mescaline. I did plenty of cannabis but while it was fun, it was never close to the psychedelic experience of psilocybin or LSD.